125 Comparative analysis of the microbiota over lesional and non-lesional skin in Hansen’s Disease

Leprosy is one of the most debilitating chronic infectious disorders which can involve virtually every organ body. Despite being advanced in sphere medical science, India still crippled by this disease a public health problem. Recently, it has been postulated that leprosy patients harbor potentially pathogenic microbes could contribute inflammation and progression disease. This study was aimed at identifying bacterial species possibly modulate mycobacterium leprae (M. leprae) over lesional non-lesional skin. Skin swab samples were taken for 70 from As part control group healthy volunteers recruited. The microbiota both groups analyse using nested Polymerase Chain Reaction-Denaturing Gradient Gel Electrophoresis (PCR-DGGE) 16S rRNA profiles. representative bacteria isolated controls Staphylococcus. Contrastingly, heavily underrepresented cases. major microorganisms obtained nonlesional skin Taxa Firmicutes Proteobacterium, respectively. These findings suggest there dysbiosis normal case leprosy. There are definitive changes core compared to unaffected individuals. Such diversity supports existence due Our results these differences commensals be utilized as potential therapeutic targets patients.